After several small television roles, Margulies achieved success in her regular role as Nurse Carol Hathaway on the NBC medical drama ER, for which she won an Emmy Award. After her departure from ER in 2000, Margulies appeared in the 2001 miniseries The Mists of Avalon and voiced the female iguanadon, Neera, in Disney's CGI film Dinosaur (2000). In 2009, she took the lead role in the American legal drama The Good Wife on CBS, for which she has won a Golden Globe and two Screen Actors Guild Awards. She won the 2011 Primetime Emmy Award for Outstanding Lead Actress in a Drama Series for her performance as Alicia Florrick on The Good Wife.
Margulies, the youngest of three daughters, was born in Spring Valley, New York. Her mother, Francesca (née Gardner), was a ballet dancer and eurythmy teacher, and her father, Paul Margulies, was a writer who wrote the Alka-Seltzer jingle "Plop, plop, fizz, fizz, oh what a relief it is". Her parents are Jewish, descended from immigrants from Austria, Hungary, and Romania. The family lived in Israel for a time before Margulies was born, before moving back to the Upper West Side of New York City.
Margulies attended grade school at Green Meadow Waldorf School and high school at High Mowing School. As a child, she lived in New York, France and England. Margulies obtained a B.A. from Sarah Lawrence College, where she appeared in several campus plays.
Margulies and attorney Keith Lieberthal were married on November 10, 2007, in Lenox, Massachusetts. Their son, Kieran Lindsay Lieberthal, was born on January 17, 2008.
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